Naphthothiazepinones

Details Naphthothiazepinones Naphthothiazepinones

C - Chemistry, Metallurgy

07

D

167/209, 260/238

C07D 281/12 (2006.01) A61K 31/55 (2006.01) C07D 281/08 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1272717

Abstract It has been found the novel compounds of the formula Image I wherein R1 is phenyl substituted with 1 to 3 lower alkoxy groups or 1 to 3 halogens, R2 is hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbonyloxy, Image or Image , R3 and R4 are, independently, lower alkyl, phenyl lower alkyl or, taken together, form a piperidine or pyrrolidine ring, n is 2 to 4 and m is 1 to 2, and pharmaceutically acceptable acid addition salts thereof have activity as calcium channel blockers and, accordingly, are useful as agents for treating ischemia and as agents for lowering blood pressure. They can be prepared by reacting a compound of the formula Image II with a compound of the formula Image III and optionally converting the compound thus obtained to a compound wherein R2 is other than hydroxy.

530430

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