Naphthyl-benzoxazepines or -benzothiazepines as squalene...

Details Naphthyl-benzoxazepines or -benzothiazepines as squalene... Naphthyl-benzoxazepines or -benzothiazepines as squalene...

C - Chemistry, Metallurgy

07

D

C07D 267/12 (2006.01) A61K 31/55 (2006.01) C07D 267/14 (2006.01) C07D 281/08 (2006.01) C07D 281/10 (2006.01) C07D 413/00 (2006.01) C07D 413/06 (2006.01) C07D 417/00 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2207772

Compounds of formula (A), wherein X is oxy, thio, -S(O)- or -S(O)2-; Y is carbonyl or methylene; R1, R2, R3 and R4 are hydrogen or substituents; R4 is alkyl or cycloalkylmethyl; and Z is an acidic residue; are useful as squalene synthetase inhibitors in the treatment of hypercholesterolemia, atherosclerosis, fungal or Alzheimer's diseases.

On décrit des composés de formule (A) où X représente oxy, thio, -(S(O)- ou S(O)¿2?-; Y représente carbonyle ou méthylène; R¿1?, R¿2?, R¿3? et R¿4? représentent hydrogène ou des substituants; R¿4? représente alkyle ou cycloalkylméthyle; et Z représente un résidu acidifère. Ces composés servent à inhiber la squalène synthétase dans le traitement de l'hypercholestérotémie, de l'athérosclérose, des mycoses ou de la maladie d'Alzheimer.

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