Naphthyloxyacetic acid derivatives

Details Naphthyloxyacetic acid derivatives Naphthyloxyacetic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/27 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) C07C 311/08 (2006.01) C07C 311/13 (2006.01) C07C 311/20 (2006.01) C07C 311/28 (2006.01) C07C 311/29 (2006.01)

Patent

CA 2137711

Naphthyloxyacetic acid derivatives of the formula: Image (I) wherein R1 represents carboxy or alkoxycarbonyl, carbamoyl optionally substituted by alkyl or hydroxyalkyl, or R1 represents hydroxymethyl; group A represents a bond or a C1-4 alkylene group or may, together with the carbon atoms at adjacent position to which it is attached, represent a 5, 6 or 7 membered ring; B represents a group -NR3SO2- or -SO2NR3- in which R3 is hydrogen, alkyl or CH2COOR7 in which R7 is hydrogen or alkyl; R2 is alkyl, alkenyl or alkynyl optionally substituted by phenyl or cycloalkyl or R2 represents napthyl; and salts thereof are PGE2 antagonists or agonists.

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