Naphthyridine compounds as inhibitors of akt activity

Details Naphthyridine compounds as inhibitors of akt activity Naphthyridine compounds as inhibitors of akt activity

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4353 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2670760

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Cette invention concerne des composés de naphthyridine substitués qui inhibent l'activité Akt. Les composés de cette invention permettent notamment, d'inhiber sélectivement une ou deux des isoformes Akt. L'invention propose aussi des compositions renfermant de tels composés inhibiteurs et des procédés permettant d'inhiber l'activité Akt en administrant le composé chez un patient nécessitant un traitement contre le cancer.

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