C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2462211
The invention relates to compounds of formula (I), in free or salt form, where R1 is a monovalent aromatic group having up to 10 carbon atoms, and R2 is a cycloaliphatic group having up to 8 ring carbon atoms. Compositions containing them, methods for their preparation and their use as phosphodiesterase isoenzyme 4 (PDE4) inhibitors are also described.
Cette invention a trait à des composés correspondant à la formule (I), sous forme libre ou sous forme de sel. Dans cette formule, R?1¿ représente un groupe aromatique monovalent ayant jusqu'à 10 atomes de carbone et R?2¿ représente un groupe cycloaliphatique ayant jusqu'à 8 atomes de carbone dans sa structure cyclique. L'invention concerne également des compositions contenant ces composés, leurs procédés de préparation et leurs utilisations en tant qu'inhibiteurs de l'iso-enzyme phosphodiestérase 4 (PDE4).
Denholm Alastair
Keller Thomas Hugo
Mccarthy Clive
Press Neil John
Taylor Roger John
Fetherstonhaugh & Co.
Novartis Ag
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