Naphthyridininones as aurora kinase inhibitors

Details Naphthyridininones as aurora kinase inhibitors Naphthyridininones as aurora kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/436 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2727103

Naphthyridinone derivative compounds that inhibit Aurora kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed Aurora kinases such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.

La présente invention concerne des composés dérivés de naphtyridinones qui inhibent les enzymes Aurora kinases, ainsi que des compositions pharmaceutiques contenant ces composés et des procédés permettant de les synthétiser. De tels composés se révèlent utiles pour le traitement de maladies prolifératives résultant dune activité non régulée et/ou déréglée des Aurora kinases, telles que des cancers, le psoriasis, des infections bactériennes et virales, des maladies inflammatoires et auto-immunes.

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