Napththalene derivatives which inhibit the cytokine or...

Details Napththalene derivatives which inhibit the cytokine or... Napththalene derivatives which inhibit the cytokine or...

C - Chemistry, Metallurgy

07

C

C07C 43/205 (2006.01) A61K 31/075 (2006.01) A61K 31/12 (2006.01) A61K 31/185 (2006.01) A61K 31/192 (2006.01) A61K 31/205 (2006.01) A61K 31/216 (2006.01) A61K 31/255 (2006.01) A61K 31/277 (2006.01) A61K 31/357 (2006.01) A61K 31/4184 (2006.01) A61K 31/585 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 45/00 (2006.01) C07C 45/46 (2006.01) C07C 49/84 (2006.01) C07C 57/50 (2006

Patent

CA 2487866

Where Y, R1-R8 and R101-R108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy.

Dans les formules (I) et (II), Y, R¿1?-R¿8? et R¿101?-R¿108? sont tels que définis dans le descriptif. L'invention porte sur des composés de la formule (II) et sur des procédés d'inhibition de la cytokine ou de l'activité biologique du facteur inhibiteur de migration du macrophage (MIF) consistant à mettre en contact MIF avec un composé de la formule (I). L'invention porte aussi sur des procédés de traitement de maladies ou de conditions dans lesquelles la cytokine MIF ou l'activité biologique est impliquée, consistant à administrer des composés de la formule (I), seuls ou dans le cadre d'une thérapie combinée.

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