Narc-1, subtilase-like homologs

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 3/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2399727

The present invention relates to a newly identified human and mouse programmed cell death (PCD) protein having homology to mammalian subtilases. The invention also relates to polynucleotides encoding the protein. The invention further relates to methods using the polypeptides and polynucleotides as a target for diagnosis and treatment in disorders mediated by or related to the protein. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the polypeptides and polynucleotides. The invention further relates to procedures for producing the polypeptides and polynucleotides.

La présente invention concerne une nouvelle protéine de mort cellulaire programmée (PCD) humaine et de souris présentant une homologie avec des subtilases mammifères. L'invention concerne également des polynucléotides codant pour ces protéines et des méthodes utilisant ces polypeptides et ces polynucléotides comme cibles pour le diagnostic et le traitement de troubles induits par cette protéine ou liés à celle-ci. L'invention se rapporte enfin à des méthodes de criblage de médicament utilisant ces polypeptides et ces polynucléotides pour identifier des agonistes et des antagonistes en vue d'un diagnostic et d'un traitement, à des agonistes et des antagonistes basés sur ces polypeptides et ces polynucléotides, et à des opérations destinées à produire lesdits polypeptides et polynucléotides.

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