Narcotic antagonist

Details Narcotic antagonist Narcotic antagonist

A - Human Necessities

61

K

A61K 31/495 (2006.01)

Patent

CA 2180085

A narcotic antagonist comprising, as its active component, a compound represented by the following formula (1) or a physiologically acceptable salt thereof: Image (1) wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom, an alkyl group, or an acyl group; R4 represents a hydrogen atom, an alkyl group, an acyl group, an alkylsulfonyl group, or a carboxyl group which may be esterified; Ar represents a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxyl group, a nitro group, an amino group, an alkylamino group, and a hydroxyl group or Ar represents a monocyclic aromatic heterocyclic ring having a nitrogen atom; m represents a number of 1 to 5 inclusive; and n represents a number of 0 to 5 inclusive. Also, a medicament for the prevention and treatment of narcotic dependence is provided. The medicament is effective in the prevention and treatment of narcosic dependence due to cocaine, etc.

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