A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/551 (2006.01) A61M 15/00 (2006.01) A61P 29/02 (2006.01)
Patent
CA 2184077
The present invention relates to the management of chronic pain without requiring administration of narcotics, and to self-management of pain on an outpatient basis. The invention further relates to facilitating detoxification and treatment of substance addiction. Accordingly, the present invention is broadly directed to a method for treating pain in a subject comprising administering via a nasal route a dose of ketamine effective to alleviate pain to a subject suffering from pain. The invention is further directed to a method for facilitating detoxification and treating substance addiction in a subject comprising administering via a nasal route a dose of ketamine effective to facilitate detoxification or treat substance addiction. In a further embodiment, the present invention provides for pulmonary administration of ketamine by inhalation. Nasal administration of ketamine advantageously allows for patient self administration of the drug, which provides for pain management or treatment of a substance addiction on an outpatient basis. Moreover, ketamine administration in nasal sprays and inhalers are generally socially acceptable. In a specific example, a patient suffering from intractable bladder pain controlled breakthrough pain by nasal administration of about 16 mg to about 32 mg of ketamine per dose.
Traitement des algies chroniques sans administration de narcotiques, autotraitement des algies à domicile et méthode facilitant la désintoxication et traitant la dépendance vis-à-vis de certaines substances. L'invention a principalement trait à une méthode consistant à administrer par voie nasale une dose à effet analgésique de kétamine, et secondairement, à une méthode facilitant la désintoxication et traitant la dépendance vis-à-vis de certaines substances consistant à administrer par voie nasale une dose efficace de kétamine. Une variante prévoit l'administration pulmonaire de kétamine par inhalation. L'administration de kétamine par voie nasale, qui présente l'avantage de permettre l'autotraitement à domicile des algies et de la dépendance vis-à-vis de substances, est de plus bien acceptée du point de vue social, lorsqu'elle est proposée en atomiseur ou en inhalateur. A titre d'exemple, un patient souffrant de douleurs tenaces de la vessie a contrôlé le seuil de douleur par l'administration par voie nasale de doses de 16 à 32 mg de kétamine.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Weg Stuart L.
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