Nasal melatonin composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/40 (2006.01) A61K 9/00 (2006.01) A61K 31/4045 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2284719

A pharmaceutical composition for intranasal administration, comprising melatonin and a pharmaceutically acceptable excipient, which is effective to cause the blood plasma melatonin concentration in a human adult, receiving an amount of melatonin in the range of 50-1000µg and in a single or simultaneous intranasal administration of said composition, to reach at least X pg/ml, within 30 minutes of said administration, wherein X is equal to 5 times the amount of melatonin, expressed in µg, in said single or simultaneous administration.

L'invention concerne une composition pharmaceutique destinée à être administrée de manière intranasale. Ladite composition contient de la mélatonine et un excipient pharmaceutiquement acceptable. Elle peut entraîner l'augmentation de la concentration de la mélatonine dans le plasma sanguin du corps d'un adulte recevant, au cours d'une administration intranasale unique ou simultanée de ladite composition, une quantité de mélatonine située entre 50 et 1000 µg. Cette augmentation peut atteindre au moins X pg/ml et ce, dans les trente minutes suivant ladite administration, X étant cinq fois supérieur à la teneur en mélatonine, exprimée en µg, de ladite administration unique ou simultanée.

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