Nasal pharmaceutical formulations and methods of using the same

Details Nasal pharmaceutical formulations and methods of using the same Nasal pharmaceutical formulations and methods of using the same

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2522291

Nasal pharmaceutical formulations comprising a drug substance having a specific particle size distribution profile are disclosed herein. Such profile provides increased bioavailability, increased efficacy or prolonged therapeutic effect of the drug substance when administered intranasally. The formulations of the present invention may comprise one or more corticosteroids having a specific particle size distribution profile. In a preferred embodiment, the corticosteroid is beclomethasone or a pharmaceutically acceptable derivative thereof for the treatment of one or more symptoms of rhinitis. Preferably, the drug substance is beclomethasone dipropionate. The formulations herein may be provided as an aqueous suspension suitable for inhalation via the intranasal route.

L'invention concerne des formulations pharmaceutiques nasales comprenant une substance médicament ayant un profil de répartition de taille de particule spécifique. Un tel profil assure une biodisponibilité accrue, une meilleure efficacité ou un effet thérapeutique prolongé de la substance médicament lors de son administration intranasale. Les formulations de cette invention peuvent renfermer un ou plusieurs corticostéroïdes ayant un profil de distribution de taille de particule spécifique. Dans un mode de réalisation préféré, le corticostéroïde est un béclométhasone ou son dérivé pharmaceutiquement acceptable et permet le traitement d'un ou plusieurs symptômes de rhinite. La substance médicament est de préférence un dipropionate de béclométhasone. Les formulations de cette invention peuvent adopter la forme d'une suspension aqueuse convenant à l'inhalation par voie intranasale.

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