Natriuretic peptide modified transferrin fusion proteins

Details Natriuretic peptide modified transferrin fusion proteins Natriuretic peptide modified transferrin fusion proteins

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2625600

Fusion proteins of transferrin and natriuretic peptides with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.

L'invention concerne des protéines hybrides de transferrine et des peptides natriurétiques présentant une demi-vie sérique ou une stabilité sérique accrue. Des protéines hybrides préférées comprennent des protéines modifiées de sorte que le fragment de transferrine présente une glycosylation nulle ou réduite, une liaison au fer et/ou une liaison au récepteur de la transferrine.

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