C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2450587
The invention relates to the identification of TIG2, the polypeptide product of Tazarotene-Induced Gene-2, as a natural ligand of the ChemR23 G-protein coupled receptor (GPCR). The invention encompasses the use of the interaction of ChemR23 polypeptides and TIG2 polypeptides as the basis of screening assays for agents that modulate the activity of the ChemR23 receptor. The invention also encompasses diagnostic assays based upon the ChemR23/TIG2 interaction, as well as kits for performing diagnostic and screening assays.
L'invention porte sur l'identification de TIG2, le produit polypeptidique du gène 2 induit par le tazatorène, comme étant un ligand naturel du récepteur couplé aux protéines G (GPCR) ChemR23. L'invention concerne en outre l'utilisation de l'interaction des polypeptides ChemR23 et des polypeptides TIG2 en tant que base pour des procédés de criblage permettant l'identification d'agents qui modulent l'activité du récepteur ChemR23. L'invention concerne également des procédés de diagnostic fondés sur l'interaction ChemR23/TIG2, ainsi que des trousses permettant la mise en oeuvre de ces procédés de diagnostic et de criblage.
Communi David
Detheux Michel
Parmentier Marc
Vandenbogaerde Ann
Wittamer Valerie
Euroscreen Sa
Smart & Biggar
LandOfFree
Natural ligand of g protein coupled receptor chemr23 and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Natural ligand of g protein coupled receptor chemr23 and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Natural ligand of g protein coupled receptor chemr23 and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1592460