C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 31/19 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/44 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2597255
The invention relates to the identification of isovaleric acid as a natural ligand of the RCC356 G-protein coupled receptor (GPCR). The invention encompasses the use of the interaction of RCC356 polypeptides and isovaleric acid as the basis of screening assays for agents that modulate the activity of the RCC356 receptor. The invention also encompasses diagnostic and other assays performed based upon the RCC356/isovaleric acid interaction, as well as kits for performing diagnostic and screening assays.
La présente invention a trait à l'identification de l'acide isovalérique sous la forme d'un ligand naturel de récepteur RCC356 couplé aux protéine G. L'invention a trait à l'utilisation de l'interaction de polypeptides RCC356 et de l'acide isovalérique comme base pour des dosages de criblages d'agents modulateurs de l'activité du récepteur RCC356. L'invention a également trait au diagnostic et à d'autres dosages effectués basés sur l'interaction entre le RCC356 et l'acide isovalérique, ainsi qu'à des trousses pour la réalisation de diagnostic et de dosages de criblage.
Philippeau Magali
Sallman Frederic
Veithen Alex
Chemcom S.a.
Smart & Biggar
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