Natural resistance associated macrophage protein and uses...

Details Natural resistance associated macrophage protein and uses... Natural resistance associated macrophage protein and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2181544

Macrophages, the main phagocytic cells of animals, can bind and ingest microorganisms. A natural resistance-associated macrophage protein is provided having an N-terminal region comprising an Src homology 3 binding domain. When present in the macrophage, the protein is capable of controlling resistance to the microorganisms.

Les macrophages, qui sont les cellules phagocytaires principales des animaux, peuvent fixer et ingérer des micro-organismes. L'invention se rapporte à une protéine naturelle de macrophage associée à la résistance aux micro-organismes qui possède une région N-terminale comprenant un domaine de liaison Src homologie 3. Lorsqu'elle est présente dans le macrophage, la protéine est capable de réguler la résistance aux micro-organismes.

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