A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 1/00 (2006.01) A61F 2/24 (2006.01)
Patent
CA 2198710
Variably compliant natural tissue valve leaflets and vascular bioprosthetics incorporating variably compliant leaflets are provided along with methods for their manufacture. The variably compliant leaflets are obtained by a chemical fixation process of the collagen molecules present in the natural tissue whereby the leaflet base sections are fixed while under greater mechanical pressure. The leaflets are relatively stiff along the leaflet base section and more flexible at the leaflet tip section. Mechanical pressure is applied by inflatable bladders contacting the base of the leaflets. The radially variable flexing characteristics of the valve leaflets promote even distribution of mechanical stress on the valve assembly during the cardiac cycle leading to improved hemodynamic performance while retarding the calcification of the leaflet tissue. Natural tissues: fascia lata or dura mater.
Valves de valvules en tissus naturels à adaptation variable, bioprothèses vasculaires les comprenant, et leur procédé de fabrication. Lesdites valves sont obtenues par un procédé chimique de fixation des molécules de collagènes présente dans les tissus naturels par lequel les sections de la base se fixent lorsqu'on exerce une plus forte pression mécanique. Les valves relativement rigides le long de leur base sont plus souples au sommet. La pression meécanique est appliquée par l'intermédiaire de vessies gonflables contractant la base des valvules. Cette souplesse variant avec le rayon assure une répartition régulière des contraintes mécaniques appliquées à la valve pendant le cycle cardiaque, ce qui en améliore les performances hémodynaiques tout en retardant la calcification de ses tissus. Les tissus naturels sont du type fascia lata ou dure-mère.
Hata Cary
Shen Shihhwa
Sung Hsing-Wen
Tu Roger
Baxter International Inc.
Edwards Lifesciences Corporation
Sim & Mcburney
LandOfFree
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