Near infrared fluorescent contrast agent and fluorescence...

Details Near infrared fluorescent contrast agent and fluorescence... Near infrared fluorescent contrast agent and fluorescence...

C - Chemistry, Metallurgy

07

D

C07D 209/14 (2006.01) A61K 49/00 (2006.01) C07D 209/60 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2344315

A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.

L'invention concerne un agent de contraste dans le proche infrarouge comprenant un composé qui renferme trois ou plus de trois groupes d'acide sulfonique dans une molécule, et un procédé d'imagerie par fluorescence qui consiste à introduire l'agent de contraste dans un organisme vivant, à exposer ledit organisme à une lumière d'excitation, et à détecter la fluorescence de l'agent de contraste dans le proche infrarouge. Ledit agent est excité par une lumière d'excitation et devient fluorescent dans le proche infrarouge, et la fluorescence de ce type a une capacité supérieure de transmission dans les tissus biologiques. Cela permet de déceler les lésions dans la partie profonde d'un organisme vivant. Par ailleurs, l'agent considéré a une meilleure solubilité dans l'eau et il est faiblement toxique, moyennant quoi son utilisation est sûre.

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