Nebulizable compositions of quaternary ammonium muscarinic...

A - Human Necessities – 61 – K

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Details

A61K 9/72 (2006.01) A61K 31/46 (2006.01) A61P 11/08 (2006.01)

Patent

CA 2653744

Compositions and methods for treatment, prevention, or amelioration of one or more symptoms of bronchoconstrictive disorders are provided. The compositions provided herein are nebulizable compositions comprising quaternary ammonium muscarinic receptor antagonists. The compositions are suitable for direct administration to a patient in need thereof via a nebulizer. Also provided are kits which comprise of the nebulizable composition of the invention in combination with a nebulizer. Also provided is a method of treating, preventing, or amelioration of one or more symptoms of bronchoconstrictive disorders by administering a therapeutically effective amount of the nebulizable composition of the invention via the use of a nebulizer to a patient in need thereof with minimal to no exposure of the nebulizable composition to the body surface of the patient.

La présente invention concerne des compositions et des procédés de traitement, de prévention ou d'atténuation d'un ou plusieurs des symptômes de la bronchoconstriction. Selon l'invention, les compositions sont des compositions nébulisables qui comprennent des ammoniums quaternaires antagonistes du récepteur muscarinique. Les compositions peuvent être administrées directement à un patient qui en a besoin au moyen d'un nébuliseur. L'invention concerne également des kits qui contiennent la composition nébulisable selon l'invention ainsi qu'un nébuliseur. L'invention concerne également un procédé de traitement, de prévention ou d'atténuation d'un ou plusieurs des symptômes de la bronchoconstriction par l'administration au moyen d'un nébuliseur d'une quantité thérapeutiquement efficace de la composition nébulisable de l'invention à un patient qui en a besoin avec un contact minimal ou nul entre la composition nébulisable et la surface du corps du patient.

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