Nebulizer formulations of dehydroepiandrosterone and methods...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/56 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/72 (2006.01) A61K 31/565 (2006.01) A61K 31/5685 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2489124

This invention relates to a sealed container containing a powder formulation comprising a dehydroepiandrosterone, its analogue(s) or salt(s) by itself or with a pharmaceutically or veterinarily acceptable carrier or diluent, and having a particle size of about 0.1 µm to about 100 µm. The formulation can be used to treat or prevent asthma, chronic obstructive pulmonary disease, lung inflammation, and other respiratory diseases or conditions. The formulation may be prepared by jet milling, and may be delivered through the respiratory tract or other routes using a nebulizer. The sealed container is provided in a device and/or a therapeutic kit.

L'invention concerne un contenant hermétique qui contient une formulation de poudre comprenant une déhydroépiandrostérone, un ou des analogue(s) ou sel(s) de celle-ci, ou un excipient pharmaceutique ou vétérinaire ou un diluant, et qui présente une taille de particules comprise entre environ 0,1 µm et environ 100 µm. La formulation peut servir à traiter ou à prévenir l'asthme, la bronchopneumopathie obstructive chronique, l'inflammation pulmonaire et d'autres maladies ou affections respiratoires. Cette formulation peut être préparée par broyage au jet et s'administre par les voies respiratoires ou par d'autres voies au moyen d'un nébuliseur. Le contenant hermétique est fourni dans un dispositif et/ou une trousse thérapeutique.

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