Nectin polypeptides, polynucleotides, methods of making and...

Details Nectin polypeptides, polynucleotides, methods of making and... Nectin polypeptides, polynucleotides, methods of making and...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/78 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2423462

This invention relates to nectin polypeptides and polynucleotides, to methods of making such polypeptides and polynucleotides, and to methods of using such polypeptides and polynucleotides to modulate cell adhesion, cell migration, and angiogenesis, to treat conditions related to cell adhesion including endothelial and epithelial cell proliferation, migration, and barrier function, and to identify agents that alter nectin polypeptide activities.

Cette invention concerne des polypeptides de nectine et des polynucléotides associés, des procédés de fabrication de tels polypeptides et polynucléotides, ainsi que des procédés d'utilisation de tels polypeptides et polynucléotides visant à moduler l'adhésion et la migration cellulaires ainsi que l'angiogénèse, traiter les états liés à l'adhésion cellulaire, y compris la prolifération cellulaire endothéliale et épithéliale, la migration et la fonction barrière, et identifier les agents qui modifient l'activité des polypeptides de nectine.

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