Needle assembly for use in delivering precise dosages of...

A - Human Necessities – 61 – B

Patent

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Details

A61B 17/34 (2006.01) A61M 5/178 (2006.01)

Patent

CA 2666248

The needle assembly of the invention is a quad-partite system for use with an arc- center stereotactic headframe that allows a clinician to deliver recombinant expression vectors through the needle assembly to targeted sites at exact depths in the brain. Methods for use of the needle assembly with a tube insert for the needle cannula that does not bind proteins, as in protein viral capsids, permit delivery of precise volumes of pharmaceutical compositions containing viral recombinant expression vectors for gene therapy.

L'invention porte sur un ensemble aiguille constitué d'un système en quatre parties utilisé avec un cadre stéréotaxique à arc central qui permet à un clinicien d'administrer, à travers l'ensemble aiguille, des vecteurs d'expression recombinants sur des sites cibles à des profondeurs exactes dans le cerveau. L'invention concerne des procédés d'utilisation de l'ensemble aiguille avec un insert tubulaire d'aiguille/cathéter qui ne lie pas les protéines, comme les protéines des capsides virales, permettant par conséquent d'administrer des volumes précis de compositions pharmaceutiques contenant des vecteurs d'expression recombinants viraux dans le cadre d'une thérapie génique.

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