Needle-free injection of formulated nucleic acid molecules

Details Needle-free injection of formulated nucleic acid molecules Needle-free injection of formulated nucleic acid molecules

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2315256

A novel method is provided for delivering nucleic acid molecules through and/or to the skin of mammals by needle-free injection. The method involves the incorporation of formulated nucleic acid molecules with devices for injecting the molecules by air, fluid and/or mechanical pressure. Disclosed are compositions and methods for enhancing the administration to and uptake of nucleic acids in a mammal. The methods disclosed provide an increased immune response by allowing the uptake of formulated nucleic acid molecules by a wide variety of cell types simultaneously. Also disclosed are examples which demonstrate that the combination of formulated nucleic acid molecules and needle-free injection methods results in immune responses which are superior to those obtained by conventional means of delivery. Methods for delivery, as well as methods for formulating nucleic acid molecules with various compounds, such as cationic complexing agents, polymeric and non-polymeric formulations, protective, interactive, non-condensing systems are also disclosed.

Cette invention concerne un procédé d'injection sans aiguille de molécules d'acides nucléiques formulées à travers et/ou à même la peau de mammifères. Ce procédé consiste en l'incorporation de molécules d'acides nucléiques formulés dans des dispositifs d'injection desdites molécules par pression d'air, de liquide ou mécanique. L'invention se rapporte à des compositions et des techniques qui améliorent l'administration et l'assimilation d'acides nucléiques chez un mammifère. Les techniques selon l'invention augmentent la réponse immunitaire en autorisant l'assimilation de molécules d'acides nucléiques formulés simultanément par des cellules de types les plus divers. Sont également fournis des exemples prouvant que l'effet conjugué de molécules d'acides nucléiques formulés et de techniques d'injection sans aiguille procure des réponses immunitaires supérieures à celles obtenues par des moyens d'administration classiques. L'invention porte également sur des techniques d'administration ainsi que sur des procédés de formulation de molécules d'acides nucléiques à partir de divers composés tels que des agents cationiques complexants, des formulations polymères et non polymères et des systèmes de protection, interactifs, sans condensation.

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