Neem component as a male contraceptive

A - Human Necessities – 61 – F

Patent

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A61F 6/20 (2006.01) A61K 35/78 (1990.01)

Patent

CA 2128649

ABSTRACT An alternate approach to vasectomy for long term male contraception following a single intra-vas application of a traditional plant (Azadirachta indica) product having immuno- modulatory properties is described. The intra-vas administration of neem oil to male rate resulted in a block of spermatogenesis without affecting the testosterone production, the seminiferous tubules, although reduced in diameter, appeared normal and contained mostly early spermatogenic cells. No antisperm antibody could be detected in the serum. Unilateral administration of neem oil in the vas resulted in a significant reduction of testicular size and spermatogenic block only on the side of application, the draining lymph node cells of the treated side also showed enhanced proliferative response to in vitro mitogen challenge. These results indicate that intra-vas application of neem oil is effective in blocking fertility in male mammals after a single injection.

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