Negative strand rna viral vector having autonomous...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/86 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/45 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2236113

A method for reconstituting Sendai viral particles by transfecting Sendai virus to a host expressing all genes for the initial replication has been developed, enabling the production of negative strand RNA vectors highly useful for practical applications.

Cette invention concerne un processus permettant de reconstituer des virions de virus sendai, lequel processus consiste à introduire un virus sendai dans un hôte dans lequel les gènes de réplication précoces ont tous été exprimés. Ce processus permet de produire un vecteur de virus d'ARN à brin négatif d'une grande valeur sur le plan pratique.

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