Neisseria meningitidis capsular polysaccharide conjugates

Details Neisseria meningitidis capsular polysaccharide conjugates Neisseria meningitidis capsular polysaccharide conjugates

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 9/00 (2006.01) C07K 14/00 (2006.01) C07K 16/12 (2006.01) C07K 17/10 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2178517

Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant reactive residues of heterobifunctional linker molecules to the polysaccharide backbone. The capsular polysaccharide is deacetylated and the heterobifunctional linker molecule is reacted with the deacetylated material and any residual amino groups are blocked by reaction with alkyl acid anhydride. The introduction of the linker molecules to the polysaccharide chain between the termini enables the polysaccharide to be linked to a carrier molecule, such as a protein, to enhance the immunogenicity of the polysaccharide. The conjugate molecule may be formulated as an immunogenic composition for raising antibodies in a host to the polysaccharide.

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