A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/095 (2006.01) A61P 31/00 (2006.01) C07H 3/06 (2006.01)
Patent
CA 2566409
The present invention relates to Neisserial Lipo-Oligo-Saccharides (LOS) that comprise a tri-saccharide outer core that shows increased binding to the DC- SIGN receptor on dendritic cells, as a result of which the Neisserial LOS~s of the invention have increased immunostimulatory activity. The tri-saccharide outer core of the Neiserial LOS~s combined with a Lipid A moiety with reduced toxicity is useful as an adjuvant in vaccine preparations.
L'invention concerne des lipo-oligosaccharides (LOS) de Neisserial comprenant une partie centrale extérieure assurant une liaison améliorée au récepteur DC-SIGN sur des cellules dendritiques, ce qui confère aux LOS de Neisserial une activité d'immunostimulation améliorée. La partie centrale extérieure du trisaccharide des LOS de Neisserial combinée à un fragment de lipide A à toxicité réduite est utile en tant qu'adjuvant dans des préparations de vaccins.
Steeghs Liana Juliana Josephine
Van de Winkel Johannes Gerardus Joseph
Van Der Ley Peter Andre
de Staat Der Nederlanden Vertegenwoordigd Door de Minister Van Vws
Gowling Lafleur Henderson Llp
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