Neisserial vaccines

C - Chemistry – Metallurgy – 12 – P

Patent

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167/129, 530/15.

C12P 21/02 (2006.01) A61K 39/095 (2006.01) C07K 14/22 (2006.01) C12N 1/20 (2006.01) C12N 15/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1338708

This invention relates to mutants of Neisseria useful for vaccine preparation. Specifically this invention relates to mutants of Neisseria containing mutations in a major outer membrane protein gene such that no immunologically functional polypeptides encoded by said gene are produced. More specifically, the invention relates to a mutant strain of Neisseria gonorrhoeae or Neisseria meningitidis having a mutation of the PIII gene or Class 4 gene respectively and to vaccines derived therefrom.

604431

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