Nell peptide expression systems and bone formation activity...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) C12N 5/07 (2010.01) A61K 31/7088 (2006.01) A61K 35/32 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61L 27/22 (2006.01) A61P 19/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2515208

The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides.

La présente invention porte d'une manière générale sur un facteur de croissance osseuse et concerne en particulier des compositions renfermant NELL1, des articles fabriqués comprenant NELL1 ainsi que des méthodes d'utilisation de NELL1 pour induire la formation osseuse. Cette invention concerne également des méthodes d'expression et de purification de peptides NELL1 et NELL2.

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