C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
530/13
C08F 8/32 (2006.01) A61K 38/16 (2006.01)
Patent
CA 1214458
Abstract of the Disclosure Novel neocarzinostatin complexes represented by the following formula (I): (SMA)n - (NCS) ........ (I) wherein n is an integer of 1-35, NCS represents neocarzino- statin residue, SMA represents a residue of a half esterified styrene-maleic acid copolymer having an average molecular weight of 1,000-10,000 in which the maleic acid portion consists of the following units. (1) maleic acid residue bound to NCS Image (2) maleic acid residue which is free or bound to NCS by non-covalent bonding Image provided that the total amount of the above described maleic acid residues (1) and (2) is from an average content of 0.1 per molecule to 60 mol % of SMA, and (3) half-esterified maleic acid residue Image wherein R is a monohydric alcohol residue or a residue of monohydroxyalkyl ether of di or trihydric alcohol, are produced by reacting neocarzinostatin - 32 - with a half esterified styrene-maleic anhydride copolymer having an average molecular weight of 1,000-10,000 and maleic anhydride residue of from an average content of 0.1 per mol- ecule to 60 mole % of SMA. These neocarzinostatin complexes have a high affinity to tumor as well as an efficient recov- ery rate through the lymphatic systems, so that the anti- cancer agent having these complexes as the active component accumulates preferentially at tumor site and the lymphaties.
422497
Ishida Nakao
Kanamaru Ryunosuke
Maeda Hiroshi
Ueda Minoru
Yoshitake Toshihiko
Kayaku Antibiotics Research Co. Ltd.
Kuraray Co. Ltd.
Maeda Hiroshi
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Yamanouchi Pharmaceutical Co. Ltd.
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