Neokine protein and nucleic acid molecules and uses therefor

Details Neokine protein and nucleic acid molecules and uses therefor Neokine protein and nucleic acid molecules and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/19 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 21/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2320144

Novel NEOKINE polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length NEOKINE proteins, the invention further provides isolated NEOKINE fusion proteins, antigenic peptides and anti-NEOKINE antibodies. The invention also provides NEOKINE nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a NEOKINE gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

L'invention a pour objet de nouveaux polypeptides, protéines et molécules d'acides nucléiques de Néokine. Outre les protéines isolées pleine longueur de Néokine, l'invention concerne des protéines de fusion isolées de Néokine, des peptides antigéniques et des anticorps anti-Néokine. L'invention se rapporte également à des molécules d'acides nucléiques de Néokine, à des vecteurs d'expression recombinants qui contiennent une molécule d'acide nucléique de cette invention, à des cellules hôtes dans lesquels on a introduit des vecteurs d'expression et à des animaux transgéniques non humains dans lesquels on a introduit ou interrompu un gène de Néokine. L'invention concerne en dernier lieu des procédés de dépistage, diagnostiques et thérapeutiques utilisant les compositions de cette invention.

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