C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 11/00 (2006.01) A61F 2/02 (2006.01) A61F 2/30 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) A61L 27/60 (2006.01) C12N 5/00 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2051663
Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces and bone are dis- closed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Op- tionally, the cells are proliferated in vitro until an adequate cell volume and density has developed for the cells to survive and pro- liferate in vivo. One advantage of the matrices is that they can be cast or molded into a desired shape, on an individual basis, so that the final product closely resembles a patient's own ear or nose, Alternatively, flexible matrices can be used which can be ma- nipulated at the time of implantation, as in a joint followed by remodeling through cell growth and proliferation in vivo. The cul- tured cells can also be maintained on the matrix in a nutrient media for production of bioactive molecules such as angiogenesis inhibiting factor, Examples are provided showing the growth of hyaline cartilage for joint relinings, the growth of elastic cartia- lage for plastic or reconstructive replacement of cartilage structures, and repair of large bone defects.
Langer Robert S.
Vacanti Charles A.
Vacanti Joseph P.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Children's Medical Center Corporation
Langer Robert S.
Massachusetts Institute Of Technology
Vacanti Charles A.
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