A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61P 25/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2571318
The present application describes a method of regenerating nerve, which steps include generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily of proteins operatively linked to a promoter; transfecting in vitro a population of cultured cells with the recombinant vector, resulting in a population of the cultured cells; and transplanting the transfected cells to an area near an injured nerve, such that expression of the DNA sequence within the area near the injured nerve causes regeneration of the nerve.
L'invention concerne un procédé pour régénérer des nerfs comprenant la production d'un vecteur plasmide ou viral recombiné comprenant une séquence ADN codant un élément d'une superfamille de facteurs de croissance de transformation de protéines liées de manière fonctionnelle à un promoteur, transfection in vitro d'une population de cellules mises en culture au moyen du vecteur recombiné, résultant d'une population de cellules mises en culture ; et transplantation des cellules transfectées dans une zone proche du nerf blessé, de sorte que l'expression de la séquence d'ADN à l'intérieur de cette zone entraîne la régénération du nerf.
Kim Chang Hwan
Lee Kwan Hee
Sim & Mcburney
Tissuegene Inc.
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