Net, a transcription factor of the tcf family, as regulator...

G - Physics – 01 – N

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Details

G01N 33/68 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C12N 15/85 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2426292

The present invention relates to the regulation of the activity of NET (ERP/SAP-2) protein and to compounds which modify or regulate NET protein activity. The invention further relates to methods of screening for agonists or antagonists of NET in order to identify new pro-angiogenic or anti- angiogenic compounds and to therapeutic uses of these compounds. The invention also relates to transgenic animals bearing mutations in NET gene.

La présente invention concerne la régulation de l'activité de la protéine NET (ERP/SAP-2), et des composés qui modifient ou régulent l'activité protéique NET. Cette invention concerne également des méthodes de criblage d'agonistes ou d'antagonistes NET en vue de l'identification de nouveaux composés pro-angiogéniques ou anti-angiogéniques, et des utilisations thérapeutiques de ces composés. Ladite invention a aussi trait à des animaux transgéniques portant des mutations au niveau du gène NET.

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