Netrin receptors

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 1/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/71 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2280290

The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

L'invention concerne des procédés et des compositions de protéines UNC-5 de vertébrés, fonctionnant en tant que protéines réceptrices des nétrines, une famille de protéines de régulation cellulaire. Ces protéines peuvent être produites par recombinaison à partir de cellules hôtes transformées à partir de ladite UNC-5 codant un acide nucléique, ou purifiées à partir de cellules humaines. L'invention concerne également des sondes et des amorces d'hybridation, capables de s'hybrider spécifiquement avec le gène unc-5 de vertébrés de la présente invention. L'invention concerne enfin des agents de liaison spécifiques de la UNC-5 de vertébrés tels que des anticorps spécifiques, ainsi que des procédés de fabrication et d'utilisation desdites compositions dans le diagnostic, la thérapie, et l'industrie biopharmaceutique.

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