Neukinase, a downstream protein of neuregulin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 38/43 (2006.01) A61P 9/00 (2006.01) C07H 21/00 (2006.01) C07K 16/16 (2006.01) C07K 16/42 (2006.01) C12N 5/16 (2006.01) C12N 5/22 (2006.01) C12N 9/48 (2006.01) C12N 15/12 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2661308

The present invention relates to neukinase, a downstream protein kinase in the neuregulin signaling pathway. In certain aspects, the present invention provides isolated neukinase-encoding nucleic acids, neukinase polypeptides, oligonucleotides that hybridize to neukinase nucleic acids, and expression vectors containing neukinase-encoding sequences. The present invention further provides isolated host cells, antibodies, transgenic non-human animals, compositions, and kits relating to neukinase. In other aspects, the present invention further provides methods of identifying predisposition to cardiac dysfunction, methods of detecting the presence of neukinase, neukinase nucleic acid, methods of screening for agents which affect neukinase activity, and methods of modulating neukinase activity.

La présente invention concerne la neukinase, une protéine kinase en aval de la voie de signalisation de la neuréguline. Selon certaines réalisations, la présente invention concerne des acides nucléiques codant la neukinase isolée, des polypeptides de la neukinase, des oligonucléotides qui s'hybrident aux acides nucléiques de la neukinase et des vecteurs d'expression contenant des séquences codant la neukinase. La présente invention concerne également des cellules hôtes isolées, des anticorps, des animaux transgéniques, des compositions et des trousses concernant la neukinase. Selon d'autres réalisations, la présente invention concerne des méthodes d'identification de la prédisposition à la déficience cardiaque, des méthodes de détection de la présence de la neukinase, de l'acide nucléique de la neukinase, des méthodes de criblage d'agents qui affectent l'activité de la neukinase et des méthodes de modulation de l'activité de la neukinase.

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