Neural regeneration using human bone morphogenetic proteins

A - Human Necessities – 61 – K

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Details

A61K 38/18 (2006.01) A61L 27/24 (2006.01) A61L 27/54 (2006.01) A61L 31/04 (2006.01) A61L 31/16 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2169191

Methods and devices are disclosed for inducing growth of neural cells, and repairing neural defects in a mammal. The method comprises administering to said mammal at the site of neural defect, damage or depletion, an effective amount of a bone morphogenetic protein, either in admixture with a pharmaceutically acceptable vehicle, or adsorbed to a suitable matrix. The device comprises bone morphogenetic protein, optionally in combination with other factors, adsorbed on a suitable matrix and contained within an artificial nerve replacement vessel.

L'invention concerne des procédés et des dispositifs servant à provoquer la croissance de cellules nerveuses et à réparer des déficiences nerveuses chez un mammifère. Le procédé comprend l'administration audit mammifère, au niveau du site de déficience, d'endommagement ou d'appauvrissement nerveux, d'une quantité efficace d'une protéine morphogénétique osseuse, soit mélangée à un véhicule acceptable pharmaceutiquement, soit adsorbée dans une matrice appropriée. Le dispositif est constitué par une protéine morphogénétique osseuse combinée éventuellement à d'autres facteurs, adsorbée sur une matrice appropriée et contenue à l'intérieur d'un vaisseau nerveux artificiel de remplacement.

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