Neural stem cells

Details Neural stem cells Neural stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/0797 (2010.01) C12N 5/0793 (2010.01) C12N 15/873 (2010.01) A61K 35/30 (2006.01) A61P 25/00 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2569978

A homogenous, symmetrically dividing population of adherent neural stem cells is obtained from ES cells or foetal or adult brain isolates, using an activator of a signalling pathway downstream of a receptor of the EGF receptor family, optionally in combination with an activator of a signalling pathway downstream of an FGF receptor. The neural stem cell population is highly pure and retains the ability to differentiate into neurons after in excess of 100 passages.

On obtient une population homogène se divisant symétriquement de cellules souches neuronales à partir de cellule Es ou foetales ou d'isolats de cerveau adulte, au moyen d'un activateur de la voie de signalisation située en aval d'un récepteur de la famille des récepteurs EGF, éventuellement en combinaison avec un activateur de la voie de signalisation située en aval d'un récepteur FGF. La population de cellules souches neuronales est hautement pure et retient la capacité de se différencier en neurones après plus de cent passages.

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