Neuralized protein, polynucleotide encoding the same, and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2309336

A gene causative of nerve mutation located in a site in the human tenth chromosome frequently suffering from deletion and having been identified; a protein (a nerve mutation factor) encoded by this gene; and an antibody against this protein. Because of showing a high homology with a Drosophila neuralized gene, this human gene causative of nerve mutation is a human homolog of the neuralized gene. Also, provision is made of a mouse neuralized gene; a protein encoded by this gene; and an antibody against the same.

Selon l'invention, un gène responsable d'une mutation nerveuse au niveau d'un site dans le dixième chromosome humain présentant fréquemment une délétion a été identifié. L'invention concerne également une protéine (un facteur de mutation nerveuse) codée par ce gène. Elle concerne en outre un anticorps contre cette protéine. Parce qu'il présente une grande homologie avec un gène neuralisé de mouche drosophile, ce gène humain responsable de cette mutation nerveuse est un homologue humain du gène neuralisé. L'invention concerne également un gène neuralisé de souris, une protéine codée par ce gène et un anticorps contre cette protéine.

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