Neuraminic acid compounds

Details Neuraminic acid compounds Neuraminic acid compounds

C - Chemistry, Metallurgy

07

D

C07D 309/28 (2006.01) A61K 31/35 (2006.01) A61K 31/365 (2006.01) A61K 31/695 (2006.01) C07D 407/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2263336

[Constitution] A neuraminic acid compound represented by the formula: (see formula 1) [wherein R1 represents a C1-C4 group which may be substituted with a halogen atom; R2, R3 and R4 may be the same or different and each represents a hydrogen atom or a C3-C25 aliphatic acyl group; and W represents a hydrogen atom or an ester residue, provided that the case where R1 is a methyl group and each of R2, R3, R4 and W is a hydrogen atom is excluded] or a pharmacologically acceptable salt thereof. [Effect] The neuraminic acid compound of the present invention exhibits excellent in vivo sialidase inhibitory activity and is useful as a therapeutic agent or a preventive agent for influenza viral infections.

L'invention concerne des composés d'acide neuraminique représentés par la formule générale (1) ou leurs sels pharmaceutiquement acceptables, formule dans laquelle R<1> représente un groupe C1-C4 éventuellement halogéné; R<2>, R<3> et R<4> représentent chacun, indépendamment, hydrogène ou un acyle aliphatique C3-C25; et W représente hydrogène ou un reste d'ester, à condition d'exclure le cas où R<1> représente méthyle et où chacun des R<2>, R<3> et R<4> et W représentent hydrogène. Ces composés ont d'excellents effets dans l'activité inhibitrice in vivo de la sialidase et peuvent être utilisés comme remède ou dans la prévention des infections dues au virus de la grippe.

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