Neuregulin variants and methods of screening and using thereof

Details Neuregulin variants and methods of screening and using thereof Neuregulin variants and methods of screening and using thereof

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61P 9/00 (2006.01) A61P 25/18 (2006.01) A61P 31/12 (2006.01) C12N 15/12 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2632152

The present invention provides polypeptide variants of neuregulin-1.beta. (NRG- 1.beta.) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of screening and producing polypeptide variants of NRG-1.beta. and methods of using polypeptide variants of NRG-1.beta. for treating diseases.

L'invention concerne des variantes polypeptidiques de la neuréguline 1ß (NRG-1ß) qui présentent une affinité de liaison accrue ou réduite à l'égard de ErbB3 et/ou de ErbB4. L'invention concerne aussi des procédés de criblage et de production de variantes polypeptidiques de NRG-1ß, et des procédés d'utilisation de variantes polypeptidiques de NRG-1ß afin de traiter des maladies.

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