Neurogenic differentiation (neurod) genes and proteins

Details Neurogenic differentiation (neurod) genes and proteins Neurogenic differentiation (neurod) genes and proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2236419

Neurogenic differentiation genes and proteins from human, mouse, and frog are identified, isolated, and sequenced. Expression of neuroD1 has been demonstrated in neural, pancreatic, and gastrointestinal cells, and expression of neuroD2 was detected in brain. Ectopic expression of neuroD1 and neuroD2 in non-neuronal cells of Xenopus embryos induced formation of neurons. NeuroD1 knock-out mice had diabetes.

Des gènes et des protéines obtenus par différentiation neurogénique à partir d'êtres humains, de souris et de grenouilles ont été identifiés, isolés et séquencés. L'expression de neuroD1 a été démontrée dans des cellules neurales, pancréatiques et gastrointestinales, et l'expression de neuroD2 a été détectée dans le cerveau. L'expression ectopique de neuroD1 et neuroD2 dans des cellules non neuronales d'embryons Xenopus a induit la formation de neuronnes. Les souris assommées avec neuroD1 ont eu du diabète.

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