Neurological drug screens

Details Neurological drug screens Neurological drug screens

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) C07K 14/48 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2207505

Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.

L'invention concerne des compositions permettant d'identifier les chefs de file pour différents agents pharmacologiques utiles dans le diagnostic ou le traitement d'affections ou de lésions neurologiques, avec un mélange à base de nétrine isolée, de récepteur de nétrine naturelle isolée comme la "Délétion dans le carcinome colo-rectal (DCC)" et de néogénine. En règle générale, le procédé consiste à incuber un mélange de nétrine mammalienne isolée, de récepteur de nétrine mammalienne naturelle isolée et d'agent pharmacologique candidat, et de déterminer ensuite si la présence de l'agent module la liaison de la nétrine sur le récepteur.

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