Neurologically-active compounds

Details Neurologically-active compounds Neurologically-active compounds

C - Chemistry, Metallurgy

07

D

C07D 239/91 (2006.01) A61K 31/436 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61K 31/473 (2006.01) A61K 31/4745 (2006.01) A61K 31/498 (2006.01) A61K 31/4985 (2006.01) A61K 31/50 (2006.01) A61K 31/5025 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 25/28 (2006.01) C07D 219/06 (2006.01) C07D 231/26 (2006.01) C07D 237/28 (2006.01) C07D 239/74 (2006.01) C07D 239/88 (2006.01) C07D 239/94 (2006.01) C07D 241/42 (2006.01) C07D 241/44 (2006.01) C07D 241/46 (2006.01) C07D 413/06 (2006.01) C07D

Patent

CA 2500952

The present invention relates to neurologically-active compounds, being heterocyclic compounds having two fused 6-membered rings with a nitrogen atom at position 1 and a hydroxy or mercapto group at position 8 with at least one ring being aromatic. Also disclosed are processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.

L'invention concerne des composés neurologiquement actifs, ceux-ci étant des composés hétérocycliques à deux cycles à 6 éléments fusionnés avec un atome d'azote en position 1, et un groupe hydroxy ou mercapto en position 8, au moins l'un des cycles étant aromatique. L'invention concerne également les procédés de préparation de ces composés et leur utilisation comme agents pharmaceutiques ou vétérinaires, en particulier, pour traiter des états neurologiques et plus spécifiquement, des états neurodégénératifs, tels que la maladie Alzheimer.

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