Neurologically-active compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/88 (2006.01) A61K 31/517 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07C 65/03 (2006.01) C07C 205/59 (2006.01) C07C 211/45 (2006.01) C07D 239/90 (2006.01) C07D 239/91 (2006.01) C07D 239/92 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/1

Patent

CA 2563038

Neurologically-active heterocyclic compounds comprising two fused 6-membered rings with nitrogen atoms at positions 1 and 3, a carboxy group at position 4,and a hydroxy group at position 8, with one ring being aromatic. Processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, and more specifically neurodegenerative conditions such as Alzheimer's disease.

La présente invention concerne des composés hétérocycliques neurologiquement actifs comprenant deux cycles à 6 segments fusionnés portant des atomes d'azote aux positions 1 et 3, un groupe carboxy en position 4, et un groupe hydroxy en position 8, l'un des cycles étant aromatique. L'invention concerne également des procédés pour l'élaboration de ces composés et leur utilisation comme agents pharmaceutiques ou vétérinaires, en particulier pour le traitement d'états neurologiques, et de façon plus spécifique des états neurodégénératifs tels que la maladie d'Alzheimer.

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