Neuromuscular blocking agents

Details Neuromuscular blocking agents Neuromuscular blocking agents

C - Chemistry, Metallurgy

07

D

C07D 217/20 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2087104

1R-cis, 1'R-cis isomer of 2',2'-(3,11-dioxo- 4,10-dioxatridecylene)-bis-(1,2,3,4-tetrahydro-6,7-di- methoxy-2-methyl-1-vera-trylisoquinolinium) salt of formula (I) (see fig. I) wherein X~ is a physiologically acceptable anion substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacologically properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockage, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockade), in comparison with the known mixture of geometrical and optical isomers.

Isomère 1R-cis,1'R-cis du sel de 2',2'-(3,11-dioxo- 4,10-dioxatridécylène)-bis- (1,2,3,4-tétrahydro-6,7-di-méthoxy-2-méthyl-1-vératrylisoquinoléinium) de formule (I) (voir fig. I) - où X~ est un anion acceptable physiologiquement et pratiquement exempt de tout autre isomère géométrique ou optique. On a constaté que l'isomère 1R-cis,1'R-cis possédait une combinaison avantageuse de propriétés pharmacologiques, notamment une plus grande capacité de blocage neuromusculaire, un taux plus faible de libération d'histamine et, à des niveaux équivalents de blocage neuromusculaire, moins d'effets nocifs sur le système nerveux autonome (blocage sympathique et parasympathique), comparativement au mélange connu d'isomères géométriques et optiques.

Affiliated with

Also associated with

Rating

Neuromuscular blocking agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neuromuscular blocking agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neuromuscular blocking agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1925569