Neuron promoter and uses

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2185788

The present invention relates to a DNA expression vector comprising a T.alpha.l .alpha.-tubulin promoter operatively linked upstream to a marker gene sequence relative to the direction of transcription in a eukaryotic expression vector adapted to be introduced into a mammal, or ancestor of the mammal at an embryonic stage, and said promoter is controlling transcription of the marker gene. The present invention also relates to a method for testing material suspected of promoting neurogenesis and neuronal growth which comprises exposing a transgenic mammal according to the present invention to said material and detecting said expressed marker gene as an indication of neurogenesis and neuronal growth.

La présente invention se rapporte à un vecteur d'expression d'ADN comprenant un promoteur de tubuline .alpha.T .alpha.l lié de manière fonctionnelle en amont à une séquence de gène de marqueur par rapport au sens de la transcription dans un vecteur d'expression eucaryote conçu pour être introduit chez un mammifère, ou un ancêtre de ce mammifère, à un stade embryonnaire, ce promoteur régulant la transcription du gène marqueur. La présente invention se rapporte également à un procédé de test d'un matériau soupçonné de favoriser la neurogénèse et le développement neuronal, qui consiste à exposer un mammifère transgénique de la présente invention audit matériau, et à détecter ledit gène marqueur exprimé comme étant l'indice d'une neurogénèse et d'un développement neuronal.

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