Neuron regulatory factor for promoting neuron survival

Details Neuron regulatory factor for promoting neuron survival Neuron regulatory factor for promoting neuron survival

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170751

A neuron regulatory factor (NRF), derived from cells of the central nervous system, is provided. NRF comprises a large polypeptide or complex of polypeptides that is antigenically distinct from several other known neurotrophic or neuron regulatory factors, and is capable of promoting survival and neurite outgrowth of cultured neurons in vitro, and preventing neuron degeneration and promoting neuron survival in vivo. NRF exerts a neurotrophic effect in a concentration-dependent manner on a variety of distinct neuron populations, and is administered as a pharmaceutical preparation to patients suffering from neuron damage or neurodegenerative disease in an amount effective to facilitate survival and recovery of damaged neurons.

L'invention concerne un facteur régulateur de neurones (NRF) dérivé de cellules du système nerveux central. NRF comprend un polypeptide, ou complexe de polypeptides, important et distinct antigéniquement de plusieurs autres facteurs régulateurs neurotrophiques ou neuronormaux et pouvant promouvoir la survie de l'excroissance des neurites de neurones cultivés in vitro, ainsi qu'empêcher la dégénérescence des neurones et promouvoir la survie des neurones in vivo. NRF exerce un effet neurotrophique d'une manière dépendante de la concentration sur une variété de populations de neurones distinctes et s'administre en tant que préparation pharmaceutique à des malades souffrant d'endommagement neuronal ou de maladie neurodégénérative, en quantité suffisante pour faciliter la survie et le rétablissement de neurones endommagés.

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