Neuronal stimulation using electrically conducting polymers

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 13/00 (2006.01) C12N 5/079 (2010.01) A61L 27/38 (2006.01) A61L 31/04 (2006.01) A61L 31/06 (2006.01) A61L 31/14 (2006.01) A61N 1/00 (2006.01) C12M 1/42 (2006.01) C12M 3/00 (2006.01)

Patent

CA 2236749

Methods and support systems are provided for modifying the regeneration, differentiation, or function of cells. In one embodiment, electrically conducting biocompatible polymers may be used alone or in combination with a polymeric support for in vitro nerve cell regeneration, or in vivo to aid in healing nervous tissue defects. The conductive polymers may be implanted adjacent to or seeded with nerve cells. Voltage or current is applied to the polymer in a range which induces the desired effect on the cells while not damaging the cells. The methods and systems can be used in a variety of applications to enhance in vivo or in vitro growth or regeneration of nervous tissue.

L'invention concerne des procédés et des systèmes de support pour modifier la régénération, la différentiation ou la fonction de cellules. Dans une forme d'exécution, on utilise des polymères biocompatibles conducteurs d'électricité seuls ou en combinaison avec un support polymère pour une régénération in vitro de cellules nerveuses ou pour aider à guérir in vivo des défauts des tissus nerveux. Les polymères conducteurs sont implantés près de cellules nerveuses ou ensemencés avec elles. Une tension ou un courant est appliqué au polymère dans une plage permettant d'induire l'effet souhaité sur les cellules, mais sans les abîmer. Les procédés et les systèmes peuvent être utilisés dans différentes applications pour améliorer la croissance ou la régénération des tissus nerveux, in vivo ou in vitro.

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