Neuropeptide receptor and uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2392309

This invention relates to the identification of an orphan G-protein coupled receptor EBI2 (and variants thereof) as a receptor of neuropeptides of the CRF family, and the use of such peptides, e.g. urotensin I or sauvagine (and analogues or mimetics of either one) as modulators for EBI2. It also relates to screening methods to identify agonists and antagonists for this neuropeptide receptor.

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